![]() ![]() Thus, axon-carrying dendrites constitute a privileged channel for excitatory synaptic input in a subset of cortical pyramidal cells.Ĭopyright © 2014 Elsevier Inc. Second, AcDs are intrinsically more excitable, generating dendritic spikes with higher probability and greater strength. First, synaptic input onto AcDs generates action potentials with lower activation thresholds compared with regular dendrites. Conductance densities in the axon, axon initial segment and hillock, soma. Multiphoton glutamate uncaging revealed that input onto the axon-carrying dendrites (AcDs) was more efficient in eliciting action potential output than input onto regular basal dendrites. This morphology is particularly enriched in central CA1, the principal hippocampal output area. However, we found that axons of hippocampal pyramidal cells frequently derive from a basal dendrite rather than from the soma. The axon initial segment, the proposed site of action potential generation, usually emanates directly from the soma. Electronic address: processing is classically conceptualized as dendritic input, somatic integration, and axonal output. 6 Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany Bernstein Center for Computational Neuroscience (BCCN) Heidelberg/Mannheim, 69120 Heidelberg, Germany.Electrical synapses contain channels that allow charges (ions) to flow from one cell to another (Fig. An electrical synapse, also known as a gap junction, is a mechanical link between two neurons that allows for the conduction of electricity. 6 Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany Bernstein Center for Computational Neuroscience (BCCN) Heidelberg/Mannheim, 69120 Heidelberg, Germany. There are two broad types of synapse: electrical and chemical.5 Institute for Anatomy and Cell Biology, Heidelberg University, 69120 Heidelberg, Germany.4 Institute of Neuroanatomy, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.3 Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.2 Laboratory for Cognition Research and Experimental Epileptology, Department of Epileptology, University of Bonn, 53127 Bonn, Germany.1 Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany Bernstein Center for Computational Neuroscience (BCCN) Heidelberg/Mannheim, 69120 Heidelberg, Germany. ![]()
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